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It was originally developed as an anti-obesity drug , hence the name: Advanced Obesity Drug-9604

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46, 47 Knock out (/) of the AT 1a receptor gene decreased baseline blood pressure 46, 48 and abolished the pressor response to Ang II infusion, 46, 49 whereas deletion of AT 1b genes did not alter baseline blood pressure, nor the pressor response to Ang II

The various precipitating factors for oculogyric crisis include the use of alcohol, some emotional stress, fatigue, and suggestibility.[] In almost all cases (95%), acute dystonia manifests within 4 days of starting an antipsychotics or after a significant increase in the dose of the antipsychotic.[] Differential diagnosis In terms of differential diagnosis of acute dystonia induced by antipsychotics, the other medications which can cause acute dystonia must be considered, which can include metoclopramide.[] Other differential diagnoses include dissociation, catatonia, tardive dystonia (usually seen after months to years of antipsychotic use and do not improve rapidly after the use of anticholinergic medications), temporal lobe epilepsy, which can lead to bizarre postures, and hypocalcemia

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